Blockchain Technology in Digital Health and Medical Technologies

Authors

  • Muhammet Damar, PhD Information Center, Dokuz Eylul University, Alsancak, İzmir, Turkiye; Upstream Lab, MAP, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada https://orcid.org/0000-0002-3985-3073
  • Ömer Aydın, PhD Associate Professor, Electrical and Electronics Engineering, Faculty of Engineering, Manisa Celal Bayar University, Manisa, Turkiye; Visiting Researcher, Management Science and Engineering, Faculty of Engineering, University of Waterloo, Waterloo, Ontario, Canada https://orcid.org/0000-0002-7137-4881
  • Fatih Safa Erenay, PhD Associate Professor, Management Science and Engineering, Faculty of Engineering, University of Waterloo, Waterloo, Ontario, Canada

DOI:

https://doi.org/10.30953/bhty.v8.409

Keywords:

Artificial intelligence, augmented reality, big data, blockchain technology, digital health, health 5.0, healthcare innovation, Internet of Things, precision medicine, telemedicine, virtual reality

Abstract

The rapid evolution of digital health technologies has introduced blockchain as an important innovation in transforming healthcare systems. This review explores the role of blockchain in driving digital health transformation and outlines future-oriented approaches that integrate emerging technologies. This paper identifies six critical areas where blockchain technology intersects with digital health innovation by systematically analyzing literature from the Web of Science and comparing topic hierarchies with results from Google Scholar. Genomics and precision medicine, telemedicine and mobile health, immersive technologies such as augmented and virtual reality, the Internet of Things and Health 5.0 environments, artificial intelligence and big data integration, and global and regional health challenges are analyzed in the study. The findings highlight how blockchain contributes to data security, Cross-border collaboration, interoperability, Device data integrity, transparency, and decentralized healthcare systems in these areas. This review aims to serve as a comprehensive resource for professionals, researchers, and policymakers seeking to understand and implement blockchain-based digital health solutions.

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References

Agbo CC, Mahmoud QH, Eklund JM. Blockchain Technology in Healthcare: A Systematic Review. Healthcare. 2019; 7(2):56. https://doi.org/10.3390/healthcare7020056

Fatoum H, Hanna S, Halamka JD, Sicker DC, Spangenberg P, Hashmi SK. Blockchain Integration with Digital Technology and the Future of Health Care Ecosystems: Systematic Review. J Med Internet Res. 2021;23(11): e19846. Published 2021 Nov 2. doi:10.2196/19846

Rehman A, Abbas S, Khan MA, Ghazal TM, Adnan KM, Mosavi A. A secure healthcare 5.0 system based on blockchain technology entangled with federated learning technique. Computers in Biology and Medicine. 2022 Nov 1; 150:106019.

Zhou F, Huang Y, Li C, Feng X, Yin W, Zhang G, Duan S. Blockchain for digital healthcare: Case studies and adoption challenges. Intelligent Medicine. 2024 Nov 28;4(04):215-25.

Zhang P, White J, Schmidt DC, Lenz G, Rosenbloom ST. FHIRChain: applying blockchain to securely and scalably share clinical data. Computational and structural biotechnology journal. 2018 Jan 1; 16:267-78.

Velmovitsky PE, Bublitz FM, Fadrique LX, Morita PP. Blockchain applications in health care and public health: increased transparency. JMIR medical informatics. 2021 Jun 8;9(6):e20713.

Lin JC, Liu YL, Hsiao WW, Fan CT. Integrating population-based biobanks: Catalyst for advances in precision health. Computational and Structural Biotechnology Journal. 2024 Dec 1;24:690-8.

Barnes C, Aboy MR, Minssen T, Allen JW, Earp BD, Savulescu J, Mann SP. Enabling demonstrated consent for biobanking with blockchain and generative AI. The American Journal of Bioethics. 2024 Nov 2:1-6.

Albalwy F, Brass A, Davies A. A blockchain-based dynamic consent architecture to support clinical genomic data sharing (ConsentChain): Proof-of-concept study. JMIR medical informatics. 2021 Nov 3;9(11):e27816.

Shabani M. Blockchain-based platforms for genomic data sharing: a de-centralized approach in response to the governance problems?. Journal of the American Medical Informatics Association. 2019 Jan;26(1):76-80.

Kuo TT, Gabriel RA, Ohno-Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. Journal of the American Medical Informatics Association. 2019 May;26(5):392-403.

Durneva P, Cousins K, Chen M. The current state of research, challenges, and future research directions of blockchain technology in patient care: Systematic review. Journal of medical Internet research. 2020 Jul 20;22(7):e18619.

Motohashi T, Hirano T, Okumura K, Kashiyama M, Ichikawa D, Ueno T. Secure and scalable mhealth data management using blockchain combined with client hashchain: system design and validation. Journal of medical Internet research. 2019 May 16;21(5):e13385.

Ichikawa D, Kashiyama M, Ueno T. Tamper-resistant mobile health using blockchain technology. JMIR mHealth and uHealth. 2017 Jul 26;5(7):e7938.

Tomaz AE, Do Nascimento JC, Hafid AS, De Souza JN. Preserving privacy in mobile health systems using non-interactive zero-knowledge proof and blockchain. IEEE access. 2020 Nov 9;8:204441-58.

Liang X, Zhao J, Shetty S, Liu J, Li D. Integrating blockchain for data sharing and collaboration in mobile healthcare applications. In 2017 IEEE 28th annual international symposium on personal, indoor, and mobile radio communications (PIMRC) 2017 Oct 8 (pp. 1-5). IEEE.

Katal A, Sethi V, Choudhury T. Potential of blockchain in telemedicine. InTelemedicine: The Computer Transformation of Healthcare 2022 Aug 25 (pp. 167-184). Cham: Springer International Publishing.

Wang W, Wang L, Zhang P, Xu S, Fu K, Song L, Hu S. A privacy protection scheme for telemedicine diagnosis based on double blockchain. Journal of Information Security and Applications. 2021 Sep 1;61:102845.

Guo R, Shi H, Zheng D, Jing C, Zhuang C, Wang Z. Flexible and efficient blockchain-based ABE scheme with multi-authority for medical on demand in telemedicine system. IEEE Access. 2019 Jun 28;7:88012-25.

Jain N, Gupta V, Dass P. Blockchain: A novel paradigm for secured data transmission in telemedicine. InWearable telemedicine technology for the healthcare industry 2022 Jan 1 (pp. 33-52). Academic Press.

Ahmad RW, Salah K, Jayaraman R, Yaqoob I, Omar M, Ellahham S. Blockchain-based forward supply chain and waste management for COVID-19 medical equipment and supplies. IEEE Access. 2021 Mar 17;9:44905-27.

Abugabah A, Nizamuddin N, Alzubi AA. Decentralized telemedicine framework for a smart healthcare ecosystem. IEEE Access. 2020 Sep 4;8:166575-88.

Damar M. Metaverse shape of your life for future: A bibliometric snapshot. Journal of Metaverse. 2021 Dec 1;1(1):1-8.

Damar M. What the literature on medicine, nursing, public health, midwifery, and dentistry reveals: An overview of the rapidly approaching metaverse. Journal of Metaverse. 2022;2(2):62-70.

Shahbazi Z, Byun YC. NLP-based digital forensic analysis for online social network based on system security. International journal of environmental research and public health. 2022 Jun 8;19(12):7027.

Lawrence L, Shreelekshmi R. Edwards curve digital signature algorithm for video integrity verification on blockchain framework. Science & Justice. 2024 Jul 1;64(4):367-76.

Hulsen T. Applications of the metaverse in medicine and healthcare. Advances in Laboratory Medicine/Avances en Medicina de Laboratorio. 2024 Jun 26;5(2):159-65.

Fang G, Sun Y, Almutiq M, Zhou W, Zhao Y, Ren Y. Distributed medical data storage mechanism based on proof of retrievability and vector commitment for metaverse services. IEEE Journal of Biomedical and Health Informatics. 2023 May 1.

Shao L, Tang WE, Zhang Z, Chen X. Medical metaverse: Technologies, applications, challenges and future. Journal of Mechanics in Medicine and Biology. 2023 Mar 12;23(02):2350028.

Moztarzadeh O, Jamshidi M, Sargolzaei S, Keikhaee F, Jamshidi A, Shadroo S, Hauer L. Metaverse and medical diagnosis: A blockchain-based digital twinning approach based on MobileNetV2 algorithm for cervical vertebral maturation. Diagnostics. 2023 Apr 20;13(8):1485.

Funk E, Riddell J, Ankel F, Cabrera D. Blockchain technology: a data framework to improve validity, trust, and accountability of information exchange in health professions education. Academic Medicine. 2018 Dec 1;93(12):1791-4.

Wu C, Tang YM, Kuo WT, Yip HT, Chau KY. Healthcare 5.0: A secure and distributed network for system informatics in medical surgery. International journal of medical informatics. 2024 Jun 1;186:105415.

Rovere G, Bosco F, Miceli A, Ratano S, Freddo G, D’Itri L, Ferruzza M, Maccauro G, Farsetti P, Camarda L. Adoption of blockchain as a step forward in orthopedic practice. European Journal of Translational Myology. 2024 May 24;34(2):12197.

Alfayez F, Bhatia Khan S. IoT-blockchain empowered Trinet: optimized fall detection system for elderly safety. Frontiers in bioengineering and biotechnology. 2023 Sep 21;11:1257676.

Kuberkar S, Singhal TK. Factors influencing the adoption intention of blockchain and internet-of-things technologies for sustainable blood bank management. International Journal of Healthcare Information Systems and Informatics (IJHISI). 2021 Oct 1;16(4):1-21.

Rajendran S. Application of blockchain technique to reduce platelet wastage and shortage by forming hospital collaborative networks. IISE Transactions on Healthcare Systems Engineering. 2021 Jan 6;11(2):128-44.

Zheng X, Sun S, Mukkamala RR, Vatrapu R, Ordieres-Meré J. Accelerating health data sharing: A solution based on the internet of things and distributed ledger technologies. Journal of medical Internet research. 2019 Jun 6;21(6):e13583.

Dwivedi AD, Srivastava G, Dhar S, Singh R. A decentralized privacy-preserving healthcare blockchain for IoT. Sensors. 2019 Jan 15;19(2):326.

Kumar R, Wang W, Kumar J, Yang T, Khan A, Ali W, Ali I. An integration of blockchain and AI for secure data sharing and detection of CT images for the hospitals. Computerized Medical Imaging and Graphics. 2021 Jan 1;87:101812.

Mantey EA, Zhou C, Anajemba JH, Okpalaoguchi IM, Chiadika OD. Blockchain-secured recommender system for special need patients using deep learning. Frontiers in Public Health. 2021 Sep 20;9:737269.

Panwar A, Bhatnagar V, Khari M, Salehi AW, Gupta G. A Blockchain Framework to Secure Personal Health Record (PHR) in IBM Cloud‐Based Data Lake. Computational Intelligence and Neuroscience. 2022;2022(1):3045107.

Kaur H, Alam MA, Jameel R, Mourya AK, Chang V. A proposed solution and future direction for blockchain-based heterogeneous medicare data in cloud environment. Journal of medical systems. 2018 Aug;42:1-1.

Yazdinejad A, Srivastava G, Parizi RM, Dehghantanha A, Choo KK, Aledhari M. Decentralized authentication of distributed patients in hospital networks using blockchain. IEEE journal of biomedical and health informatics. 2020 Jan 27;24(8):2146-56.

Subramanian H, Subramanian S. Improving diagnosis through digital pathology: Proof-of-concept implementation using smart contracts and decentralized file storage. Journal of medical Internet research. 2022 Mar 28;24(3):e34207.

Chapala V, Bojja P. IoT based lung cancer detection using machine learning and cuckoo search optimization. International Journal of Pervasive Computing and Communications. 2021 Dec 10;17(5):549-62.

Tagliafico AS, Campi C, Bianca B, Bortolotto C, Buccicardi D, Francesca C, Prost R, Rengo M, Faggioni L. Blockchain in radiology research and clinical practice: Current trends and future directions. La radiologia medica. 2022 Apr;127(4):391-7.

Durga R, Poovammal E. Fled-block: Federated learning ensembled deep learning blockchain model for covid-19 prediction. Frontiers in Public Health. 2022 Jun 17;10:892499.

Zheng X, Vieira A, Marcos SL, Aladro Y, Ordieres-Meré J. Activity-aware essential tremor evaluation using deep learning method based on acceleration data. Parkinsonism & related disorders. 2019 Jan 1;58:17-22.

Khurshid A, Gadnis A. Using blockchain to create transaction identity for persons experiencing homelessness in America: policy proposal. JMIR research protocols. 2019 Mar 6;8(3):e10654.

Benchoufi M, Ravaud P. Blockchain technology for improving clinical research quality. Trials. 2017 Dec;18(1):1-5.

Till BM, Peters AW, Afshar S, Meara JG. From blockchain technology to global health equity: can cryptocurrencies finance universal health coverage?. BMJ global health. 2017 Dec 1;2(4):e000570.

Lee HA, Kung HH, Lee YJ, Chao JC, Udayasankaran JG, Fan HC, Ng KK, Chang YK, Kijsanayotin B, Marcelo AB, Hsu CY. Global infectious disease surveillance and case tracking system for COVID-19: development study. JMIR medical informatics. 2020 Dec 22;8(12):e20567.

Khan RU, Kumar R, Haq AU, Khan I, Shabaz M, Khan F. Blockchain-based trusted tracking smart sensing network to prevent the spread of infectious diseases. IRBM. 2024 Apr 1;45(2):100829.

Karabekmez ME. Data ethics in digital health and genomics. The New Bioethics. 2021 Oct 2;27(4):320-33.

Mackey TK, Kuo TT, Gummadi B, Clauson KA, Church G, Grishin D, Obbad K, Barkovich R, Palombini M. ‘Fit-for-purpose?’–challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC medicine. 2019 Mar 27;17(1):68.

Kumar D. Benefits and Roles of Blockchain in Genomics. In: Malviya R, Sundram S, editors. Blockchain for Healthcare 4.0. Boca Raton: CRC Press; 2023. p. 224-244.

Brogan J, Baskaran I, Ramachandran N. Authenticating health activity data using distributed ledger technologies. Comput Struct Biotechnol J. 2018;16:257-266.3

Griggs KN, Ossipova O, Kohlios CP, Baccarini AN, Howson EA, Hayajneh T. Healthcare blockchain system using smart contracts for secure automated remote patient monitoring. J Med Syst. 2018;42(7):130.

Agrali O, Aydin O. Tweet classification and sentiment analysis on metaverse related messages. J Metaverse. 2021;1(1):25-30.

Karaarslan E, Aydin O, Yazici Yilmaz S, Tinmaz H, Eken S, Gokce Narin N, et al. Shaping the future of metaverse research: innovation, collaboration, and Journal of Metaverse’s academic impact. J Metaverse. 2025;5(2):73-91.

Verma A, Bhattacharya P, Madhani N, Trivedi C, Bhushan B, Tanwar S, et al. Blockchain for industry 5.0: vision, opportunities, key enablers, and future directions. IEEE Access. 2022;10:69160-91.

Gupta KK, Saha S, Sahoo SK, Goswami SS. Revolutionizing healthcare industry 5.0: exploring the potential of blockchain technology for medical applications. J Technol Innov Energy. 2023;2(3):76-93.

Sizan NS, Dey D, Layek MA, Uddin MA, Huh EN. Evaluating blockchain platforms for IoT applications in industry 5.0: a comprehensive review. Blockchain: Res Appl. 2025;100276.

Abed SA, Gök M. Big data and artificial intelligence on the blockchain: a review. Babylon J Artif Intell. 2023:1-4.

Pablo RGJ, Roberto DP, Victor SU, Isabel GR, Paul C, Elizabeth OR. Big data in the healthcare system: a synergy with artificial intelligence and blockchain technology. J Integr Bioinform. 2022;19(1):20200035.

Alici S, Damar M, Goksen Y. Blok zincir teknolojisine akademik yönden ne kadar hazırız: Türkiye adresli blok zincir konusundaki uluslararası yayınların analizi ve alanın gelişimine yönelik öneriler. J Inf Syst Manag Res. 2024;6(1):40-62.

Damar M, Aydin O, Erenay FS. Blockchain applications in core healthcare services: patient data, research, and institutional processes. Blockchain Healthc Today. 2025;8(2):408.

Damar M, Pinto AD, Erenay FS, Aydin O. Impact of COVID-19 on primary health care research trends and suggestions for better services approaches via blockchain based applications: impact of COVID-19 on PHC & blockchain based applications. Blockchain Healthc Today. 2025;8(1):400.

Ghosh PK, Chakraborty A, Hasan M, Rashid K, Siddique AH. Blockchain application in healthcare systems: a review. Systems. 2023;11(1):38.

Ng WY, Tan TE, Movva PV, Fang AHS, Yeo KK, Ho D, et al. Blockchain applications in health care for COVID-19 and beyond: a systematic review. Lancet Digit Health. 2021;3(12):e819-e829.

Elangovan D, Long CS, Bakrin FS, Tan CS, Goh KW, Yeoh SF, et al. The use of blockchain technology in the health care sector: systematic review. JMIR Med Inform. 2022;10(1):e17278.

Hasselgren A, Kralevska K, Gligoroski D, Pedersen SA, Faxvaag A. Blockchain in healthcare and health sciences—A scoping review. Int J Med Inform. 2020;134:104040.

Abu-Elezz I, Hassan A, Nazeemudeen A, Househ M, Abd-Alrazaq A. The benefits and threats of blockchain technology in healthcare: a scoping review. Int J Med Inform. 2020;142:104246.

Silvano WF, Marcelino R. Iota Tangle: a cryptocurrency to communicate Internet-of-Things data. Future Gener Comput Syst. 2020;112:307-19.

Shameer K, Badgeley MA, Miotto R, Glicksberg BS, Morgan JW, Dudley JT. Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams. Brief Bioinform. 2017;18(1):105-24.

Alghazwi M, Turkmen F, Van Der Velde J, Karastoyanova D. Blockchain for genomics: a systematic literature review. Distributed Ledger Technol: Res Pract. 2022;1(2):1-28.

Caskey T. Precision medicine: functional advancements. Annu Rev Med. 2018;69(1):1-18.

Kaya A, Gümüş R, Aydın Ö. Sağlık verilerinde istatistiksel zaman serisi yaklaşımı ile aykırılık analizi. In: Uluslararası Avrasya Sağlık Bilimleri Kongresi (IEHSC 2021). Trabzon, Turkey; 2021. p. 160-1.

Kaya A, Gümüş R, Aydın Ö. Time series outlier analysis for model, data and human-induced risks in COVID-19 symptoms detection. Middle East J Sci. 2021;7(2):123-36.

Gautam S, Menon M, Rana R. The role of blockchain in genomics sciences. In: Blockchain in Health Sciences. 2025. p. 411-40.

Ullah HS, Aslam S. Blockchain in healthcare and medicine: a contemporary research of applications, challenges, and future perspectives. arXiv preprint arXiv:2004.06795. 2020.

Ahmed E, Shabani M. DNA data marketplace: an analysis of the ethical concerns regarding the participation of the individuals. Front Genet. 2019;10:1107.

Wjst M. Caught you: threats to confidentiality due to the public release of large-scale genetic data sets. BMC Med Ethics. 2010;11(1):21.

Yue X, Wang H, Jin D, Li M, Jiang W. Healthcare data gateways: found healthcare intelligence on blockchain with novel privacy risk control. J Med Syst. 2016;40(10):218.

Aydın Ö, Karaarslan E. Covid-19 belirtilerinin tespiti için dijital ikiz tabanlı bir sağlık bilgi sistemi. In: Online International Conference of COVID-19 (CONCOVID); 12-14 June 2020; İstanbul, Türkiye.

Guo F, Xiao X, Hecker A, Dustdar S. Characterizing IOTA tangle with empirical data. In: GLOBECOM 2020-2020 IEEE Global Communications Conference; 2020 Dec; IEEE. p. 1-6.

Kaufman D. Expulsion: a type of forced mobility experienced by homeless people in Canada. Urban Geogr. 2022;43(3):321-43.

Alpert JS. Homeless in America. Am J Med. 2021;134(3):295-6.

Paudyal V, Vohra N, Price M, Jalal Z, Saunders K. Key causes and long-term trends related to emergency department and inpatient hospital admissions of homeless persons in England. Int J Emerg Med. 2023;16(1):48.

Published

2025-12-06

How to Cite

Damar, M., Aydin, O., & Erenay, F. S. (2025). Blockchain Technology in Digital Health and Medical Technologies. Blockchain in Healthcare Today, 8(3). https://doi.org/10.30953/bhty.v8.409

Issue

Section

Narrative/Systematic Review/Meta-Analysis